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Updated: Nov 13, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis and characterization of new pyrazole-tetrazole derivatives as new vasorelaxant agents
Mounir Cherfi1, Ikram Dib2, Tarik Harit1
1Laboratory of Applied Chemistry and Environment-ECOMP, Faculty of Sciences, Mohammed First University Bd Mohamed VI, Oujda, Morocco.
Abstract:
The synthesis of new functionalized tetrazole-pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 "ethyl 1-((2-(3-bromopropyl)-2H-tetrazol-5-yl)methyl)-5-methyl-1H-pyrazole-3-carboxylate" seems to have the highest effect, which reached 70% at 10-4 M concentration. This effect was partially endothelium-dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.
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