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Updated: Nov 13, 2025

Development of Leishmania Species Strains with Constitutive Expression of eGFP
Published on: April 21, 2023
Genetic diversity of Leishmania tropica: Unexpectedly complex distribution pattern
Arzuv Charyyeva1, Ülfet Çetinkaya2, Bora Özkan3
1Life Science Research Centre, Faculty of Science, University of Ostrava, 702 00 Ostrava, Czech Republic.
Abstract:
In this study, we characterized a collection of clinical samples obtained from Syrian and Turkish patients with cutaneous leishmaniasis using internal transcribed spacer 1 (ITS1) sequences. All obtained sequences belonged to Leishmania tropica. Combining them with those available from GenBank allowed us performing a broad-scale analysis of genetic diversity for this species. We demonstrated that L. tropica has a complex phylogeographic pattern with some haplotypes being widespread across endemic countries and others restricted to particular regions. We hypothesize that at least some of them may be associated with alternative vectors or animal reservoirs.
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