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Roles of matrix metalloproteinase-7 (MMP-7) in cancer

Hai-Yang Liao1, Chao-Ming Da1, Bei Liao2

  • 1The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China.

Clinical Biochemistry
|March 13, 2021
PubMed

Insights

Matrix metalloproteinase-7 (MMP-7) is a key enzyme regulating extracellular matrix. This review highlights MMP-7

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase.
  • MMP-7 degrades extracellular matrix components and other substrates.
  • It plays critical roles in physiological processes like wound healing and bone remodeling.

Purpose of the Study:

  • To review the role of MMP-7 in human cancer development.
  • To elucidate the underlying mechanisms of MMP-7 in carcinogenesis.
  • To discuss the clinical significance of MMP-7 as a biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on MMP-7 in cancer.
  • Analysis of MMP-7's involvement in cancer cell proliferation, differentiation, metastasis, and invasion.
  • Examination of MMP-7 expression correlation with clinical characteristics.

Main Results:

  • MMP-7 regulates cancer cell behavior through various mechanisms.
  • MMP-7 expression is linked to clinical features of cancer patients.
  • MMP-7 serves as a potential diagnostic and prognostic biomarker.

Conclusions:

  • MMP-7 is implicated in the occurrence and progression of various human cancers.
  • Targeting MMP-7 offers a potential therapeutic strategy for cancer and other diseases.
  • MMP-7's expression profile is a significant indicator for disease diagnosis and prognosis.
Keywords:
CarcinogenLandmarkMatrix metalloproteinase-7 cancerMechanismTherapeutic target

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