Related Experiment Video
Updated: Nov 13, 2025
12:36
Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology
Published on: March 14, 2020
16.8K
Liver X receptors and liver physiology
Lillian Russo-Savage1, Ira G Schulman1
1Department of Pharmacology, University of Virginia, School of Medicine, United States of America.
Biochimica Et Biophysica Acta. Molecular Basis of Disease
|March 13, 2021
Summary
Liver X Receptors (LXRs) control cholesterol and fatty acid metabolism. Modulating LXR activity offers potential therapeutic strategies for liver diseases by influencing lipid homeostasis.
Area of Science:
- Biochemistry
- Molecular Biology
- Hepatology
Background:
- Liver X Receptors (LXRs), including LXRα and LXRβ, are nuclear receptors.
- They are ligand-dependent transcription factors activated by cholesterol derivatives.
- LXRs play a crucial role in regulating lipid homeostasis body-wide.
Purpose of the Study:
- To review the role of LXRs in regulating cholesterol metabolism in the liver.
- To examine the influence of LXRs on fatty acid metabolism.
- To discuss the potential of modulating LXR activity in treating liver diseases.
Main Methods:
- Review of existing literature on LXR function.
- Analysis of studies utilizing genetic knockouts of LXR genes.
- Examination of research involving synthetic LXR ligands.
Main Results:
- LXRs are key regulators of cholesterol and fatty acid metabolism.
- LXR activity directly impacts lipid homeostasis within the liver.
- Evidence suggests LXR modulation affects liver disease pathology.
Conclusions:
- LXRs are critical targets for understanding and treating liver-related metabolic disorders.
- Targeting LXRs may offer novel therapeutic avenues for liver diseases.
- Further research into LXR modulation is warranted for liver disease management.
Related Concept Videos
01:30Liver Physiology
2.7K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
2.7K
01:24Liver Regeneration
3.8K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.8K
01:27Liver Histology
2.9K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
2.9K
01:31Transducer Mechanism: Nuclear Receptors
2.0K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
2.0K
01:17Gross Anatomy of the Liver
1.4K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
1.4K
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
57
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
57