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Related Experiment Video

Updated: Nov 13, 2025

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

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Photocoagulation for retinal vein occlusion.

Sohan Singh Hayreh1

  • 1Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, IA, USA.

Progress in Retinal and Eye Research
|March 13, 2021
PubMed
Summary
This summary is machine-generated.

Photocoagulation was historically used for retinal vein occlusion (RVO) complications like macular edema and neovascularization. Newer therapies have significantly altered its role in managing these RVO conditions.

Keywords:
Anti-VEGF therapyBranch retinal vein occlusionCentral retinal vein occlusionCorticosteroid therapyHemi-central retinal vein occlusionLaser photocoagulationMacular edemaNeovascular glaucomaOcular neovascularizationPanretinal photocoagulationPhotocoagulationRetinal vein occlusion

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Area of Science:

  • Ophthalmology
  • Retinal diseases
  • Vascular disorders

Background:

  • Retinal vein occlusion (RVO) can lead to severe vision loss from macular edema and neovascularization (NV), including neovascular glaucoma (NVG).
  • Understanding RVO classification, NV pathogenesis, and natural history is key to managing complications.

Purpose of the Study:

  • To review the historical and current role of photocoagulation in managing macular edema and NV in central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO).
  • To discuss findings from clinical trials on photocoagulation for RVO and its evolving place alongside new therapies.

Main Methods:

  • Review of historical data and clinical trials concerning photocoagulation for RVO.
  • Discussion of the pathogenesis of ocular NV in ischemic CRVO.
  • Analysis of the impact of intravitreal anti-VEGF and corticosteroid therapies on photocoagulation's role.

Main Results:

  • Photocoagulation was used to prevent/treat NV and NVG in ischemic CRVO.
  • Clinical trials evaluated photocoagulation for NV and macular edema in CRVO and BRVO.
  • Intravitreal therapies have significantly changed the management paradigm for RVO complications.

Conclusions:

  • Photocoagulation played a significant role in managing RVO complications, particularly NVG.
  • The advent of anti-VEGF and corticosteroid injections has diminished the primary role of photocoagulation.
  • Current management strategies for RVO must consider these newer, effective treatment options.