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Delirium and Mortality in Coronavirus Disease 2019 (COVID-19) - A Systematic Review and Meta-analysis

Raymond Pranata1, Ian Huang2, Michael Anthonius Lim1

  • 1Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.

Archives of Gerontology and Geriatrics
|March 13, 2021
PubMed

Insights

Delirium significantly increases mortality risk in older adults hospitalized with COVID-19. This meta-analysis confirms a strong association between delirium and death in this vulnerable population.

Area of Science:

  • Gerontology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Older adults are disproportionately affected by COVID-19.
  • Delirium is a common complication in hospitalized patients.
  • The association between delirium and mortality in COVID-19 patients requires further investigation.

Purpose of the Study:

  • To conduct a meta-analysis to determine the association between delirium and mortality in older adults with COVID-19.
  • To synthesize evidence from existing studies on this topic.

Main Methods:

  • Systematic literature searches of PubMed, Embase, and Scopus databases were conducted.
  • Studies included patients diagnosed with delirium using validated criteria.
  • Mortality was the primary outcome, with effect estimates reported as odds ratios (ORs) and adjusted odds ratios (aORs).

Main Results:

  • The meta-analysis included 3,868 patients from 9 studies.
  • Delirium was present in 27% of patients and was significantly associated with mortality (OR 2.39).
  • Adjusted analysis confirmed delirium as an independent predictor of mortality (aOR 1.50), with subgroup analysis showing similar associations for delirium at admission.

Conclusions:

  • Delirium is associated with an increased risk of mortality in hospitalized older adults with COVID-19.
  • The findings highlight the importance of monitoring and managing delirium in this patient group.
  • Further research should explore interventions to mitigate delirium-related mortality in COVID-19 patients.
Abstract

Keywords:
ConfusionDeliriumGeriatricSARS-CoV-2Severe

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