A semi-quantitative risk ranking of potential human exposure to engineered nanoparticles (ENPs) in Europe

Large quantities of engineered nanoparticles (ENPs) have emerged on the European market with the rapid development of nanotechnology, however knowledge of potential health risks to humans remains in its infancy. The ENP safety issue is of pressing concern as their novel physicochemical characteristics have been illustrated compared to other bulk-form counterparts. Therefore, it is critical to carry out a comprehensive risk assessment for ENPs to guide risk management in industrial sectors. Based on current data availability, a risk ranking model is developed in accordance with the European Chemicals Agency (ECHA) advice for ENP risk assessment. In this study a Quantity, Exposure, Hazard (QEH) risk scoring model was adopted for characterizing both quantitative and qualitative data, including potential exposure pathways and hazard information. Scores were assigned to quantities of ENPs used in consumer products, intake likelihoods (oral, inhalation, and dermal intake), and hazard potential. Exposure through environmental routes and through consumer products are regarded as significant potential exposure routes. This model prioritized ENPs used in Europe according to human health risk potential. Nano-titanium dioxide (TiO₂) ranked the highest, resulting from exposure through consumer products. Silver nanoparticles (AgNP), as the second most critical ENP, is of most concern in terms of the risk from environmental sinks. Regarding the compartmentalization of total ENP risks to humans, the consumption of consumer products with nano-ingredients, especially nano-TiO₂, nano-silicon dioxide (SiO₂), and AgNP, constitutes the majority of the QEH risk index. The inadequacy of ENP risk management procedures is highlighted, not only during manufacturing, but also during nanomaterial waste disposal processes from marketplace through to the environment. Current risk assessments are based upon recent knowledge of the ENP class as novel pollutants, highlighting the need for further quantification of underlying risks as data emerges.