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Cronkhite–Canada syndrome

Anita Nagy1, Levente Tóth1, János Theisz1

  • 11 Szent Imre Egyetemi Oktatókórház, Gasztroenterológia Profil, Budapest, Tétényi út 12-16., 1115.

Orvosi Hetilap
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Summary

Cronkhite-Canada syndrome is a rare noninherited disorder causing gastrointestinal polyposis and protein-losing enteropathy. This case report details a 71-year-old male diagnosed and treated for this condition.

Keywords:
Cronkhite–Canada syndromeCronkhite–Canada-szindrómafehérjevesztő enteropathiagastrointestinal polyposisonychodystrophiaonychodystrophypolyposisszindrómaprotein-losing enteropathy

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Rare Diseases

Background:

  • Cronkhite-Canada syndrome (CCS) is an extremely rare, noninherited disorder.
  • It is characterized by gastrointestinal polyposis, protein-losing enteropathy, and ectodermal abnormalities.
  • The etiology is largely unknown, with autoimmune mechanisms suspected.

Observation:

  • A case of a 71-year-old male patient presenting with symptoms suggestive of CCS.
  • Diagnosis was confirmed through patient history, physical examination, endoscopic findings, and histology.
  • This represents the first reported case of CCS in Hungary.

Findings:

  • The patient was diagnosed with Cronkhite-Canada syndrome.
  • Treatment involved a combination of proton-pump inhibitor, corticosteroids, and mesalazine.
  • Nutritional therapy was also administered as part of the management plan.

Implications:

  • This case highlights the importance of recognizing and diagnosing rare conditions like CCS.
  • The presented treatment regimen, based on literature, offers a potential therapeutic approach.
  • Further research into the etiology and optimal management of CCS is warranted.