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Related Experiment Videos

Are corneocytes elastic?

J L Lévêque1, M C Poelman, J de Rigal

  • 1Laboratoires de Recherche de l'Oréal, Département de Biophysique, Aulnay-sous-Bois, France.

Dermatologica
|January 1, 1988
PubMed
Summary
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The stratum corneum is a flexible material. Deformations occur due to intercellular changes and microrelief unfolding, not corneocyte stretching, suggesting desmosomes play a role in cell cohesion.

Area of Science:

  • Biophysics
  • Materials Science
  • Dermatology

Background:

  • The stratum corneum provides mechanical protection to the skin.
  • Understanding its mechanical properties is crucial for drug delivery and skincare formulation.

Purpose of the Study:

  • To investigate the mechanical properties of isolated corneocytes and the stratum corneum.
  • To elucidate the deformation mechanisms within the stratum corneum.

Main Methods:

  • Utilized a microhandling system to measure the force required for elongating isolated corneocytes.
  • Observed the disassembly of corneocyte aggregates under varying forces.

Main Results:

  • The elastic modulus of isolated corneocytes is significantly higher than that of the stratum corneum.

Related Experiment Videos

  • Stratum corneum deformation primarily involves plastification of the intercellular medium and unfolding of microrelief lines.
  • Desmosome remnants may contribute to corneocyte cohesiveness.

    • Conclusions:

    • The stratum corneum behaves as a highly supple material.
    • Corneocyte elongation is not the primary mechanism of deformation in the stratum corneum.
    • Intercellular components and desmosomes are key factors in stratum corneum mechanics.