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Updated: Nov 13, 2025

High-resolution Imaging of Nuclear Dynamics in Live Cells under Uniaxial Tensile Strain
Published on: June 2, 2019
The characteristics of nuclear membrane fluctuations in stem cells
Sedigheh Ghanbarzadeh Nodehi1, G V Shivashankar2,3, Jacques Prost4,5
1Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran.
Abstract:
We analyse the stem cell nucleus shape fluctuation spectrum obtained from optical confocal microscopy on an hour time scale with 10 s resolution. In particular, we investigate the angular and time dependencies of these fluctuations, define appropriate correlation functions that reveal the fundamentally out of equilibrium nature of the observed fluctuations as well as their global anisotropy. Langevin equations respecting the symmetry of the system allow us to model the damped oscillatory behaviour of the time correlations.
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