Severe hypercalcaemia and acute renal failure in an infant with subcutaneous fat necrosis
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Updated: Nov 13, 2025

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Published on: July 19, 2018
Tülay İnce Becerir1, Ayça Altincik1, Bayram Özhan1
1Divisions of Nephrology and Endocrinology, Department of Paediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey.
Abstract:
Subcutaneous fat necrosis (SFN) in the newborn is a form of panniculitis which presents with erythematous nodules and indurated plaques. Severe life-threatening hypercalcaemia can occur as a late complication. A 2-month-old girl presented with severe hypercalcaemia and acute renal injury as a complication of SFN. She was admitted to hospital with the chief complaint of failure to thrive. She had a history of therapeutic hypothermia. After successful treatment of the hypercalcaemia with bisphosphonates, the acute renal injury recovered spontaneously. In neonates with SFN, acute renal injury is a rare complication of hypercalcaemia. Timely prevention of the complications of hypercalcaemia in SFN is essential.
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