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Elimination of Senescent Endothelial Cells: Good or Bad Idea?
Nadine Martin1, Anda Huna1, David Bernard1
1Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France.
Trends in Cell Biology
|March 15, 2021
Abstract:
Cellular senescence has a critical role in many physiopathological contexts. Recent studies highlight the beneficial and adverse effects that eliminating senescent endothelial cells can have on health span, questioning the current development of drugs that induce the death of senescent cells, named senolytics, as a therapeutic strategy.
