Related Experiment Video
Updated: Nov 13, 2025
07:44
Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.8K
Innate and adaptive immune cells in Tumor microenvironment
1Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru - 562157, India.
The Gulf Journal of Oncology
|March 15, 2021
Summary
Immune cells in the tumor microenvironment release mediators that promote cancer. Understanding these innate and adaptive immune cell roles is key to developing new cancer therapies.
Area of Science:
- Immunology
- Oncology
- Cancer Biology
Background:
- Immune cells are recruited to the tumor microenvironment by chemokines.
- These immune cells respond to various noxious stimuli, including physical, chemical, and infectious agents.
Purpose of the Study:
- To highlight the critical role of innate and adaptive immune cells within the tumor microenvironment.
- To elucidate the mechanisms by which immune cells influence tumor development.
Main Methods:
- Review of scientific literature on immune cell involvement in cancer.
- Analysis of chemokine-mediated recruitment and inflammatory mediator release by immune cells.
Main Results:
- Innate and adaptive immune cells release inflammatory mediators like cytokines, chemokines, and growth factors.
- Activation of transcription factors such as NF-κB, STAT3, and HIF-1α by immune cells contributes to tumor initiation, promotion, and progression.
Conclusions:
- Immune cells play a significant role in all stages of tumor development.
- Targeting immune cell functions within the tumor microenvironment presents a potential therapeutic strategy for cancer treatment.
Related Concept Videos
02:17The Tumor Microenvironment
7.2K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.2K
02:53Adaptive Mechanisms in Cancer Cells
6.1K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.1K
01:27Tumor Immunotherapy
824
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
824
01:40Cell-mediated Immune Responses
79.6K
Overview
79.6K
01:28Cells of the Innate Immune Response
7.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
7.8K
01:23Cells of the Adaptive Immune Response
7.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
7.3K