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Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19

Maria G Balta1, Evangelos Papathanasiou2,3, Panagiotis F Christopoulos4

  • 1The CrossTalk Group, Institute of Oral Biology, University of Oslo, Oslo, Norway.

Frontiers in Immunology
|March 15, 2021
PubMed

Insights

Specialized pro-resolving mediators (SPMs) can help manage COVID-19 by regulating macrophage activity and reducing cytokine storms. SPMs offer therapeutic potential for COVID-19 by promoting inflammation resolution and a pro-resolving macrophage phenotype.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathogenesis

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic causes significant global health and economic impact.
  • Macrophages play a central role in COVID-19 pathogenesis and lethality.
  • Managing the macrophage-induced cytokine storm is crucial for COVID-19 treatment.

Purpose of the Study:

  • To review the homeostatic functions of specialized pro-resolving mediators (SPMs) on macrophages.
  • To discuss the molecular links between lipid mediators and COVID-19 severity.
  • To explore the clinical potential of SPMs in COVID-19 immunotherapeutics.

Main Methods:

  • Literature review of scientific articles on SPMs, macrophages, and COVID-19.
  • Analysis of molecular mechanisms underlying SPM-macrophage interactions.
  • Evaluation of existing and potential clinical applications of SPMs.

Main Results:

  • SPMs regulate macrophage infiltration and cytokine production.
  • SPMs promote a pro-resolving macrophage phenotype, aiding inflammation resolution.
  • Specific molecular pathways link lipid mediators to COVID-19 severity.

Conclusions:

  • SPMs demonstrate significant therapeutic potential in managing COVID-19.
  • Targeting macrophage-mediated inflammation with SPMs is a promising immunotherapeutic strategy.
  • Further clinical investigation of SPMs for COVID-19 is warranted.
Keywords:
cytokine stormlipid mediators/specialized pro-resolving mediators (SPMs)macrophage activation syndrome (MAS)resolution of inflammationsevere acute respiratory syndrome corona virus (SARS-CoV2)

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