Primary aneuploid lymphoma of the uterine cervix: a case report

A primary, diffuse, centroblastic lymphoma of the uterine cervix is described. The patient is a 77-year-old V-parous woman, who presented with postmenopausal bleeding, but no systemic symptoms. Gynecologic examination revealed a 4 x 8-cm tumor extending from the uterine cervix to the anterior vaginal wall and elevating the bladder neck, but with no sign of mucosal infiltration. According to the FIGO classification, the tumor was classified as stage IIIA. Flowcytometric analysis showed a grossly aneuploid tumor, with a DNA content of 3.5c. The S-phase rate was 30.6%. The patient was treated with external pelvic irradiation to 46 Gy. Six weeks later the therapy was completed with seven courses of a cyclophosphamide-vincristine-prednisolone (COP) regimen. Complete tumor response was achieved and 3 years later there is no sign of relapse. Despite unfavorable prognostic parameters: large tumor volume, diffuse growth pattern, aneuploidy, and a high S-phase rate, a combination of radiotherapy and chemotherapy was found to be a successful treatment of this rare form of advanced primary lymphoma of the uterine cervix.