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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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The Association of Hereditary Prothrombotic Risk Factors with ST-Elevation Myocardial Infarction

İbrahim Halil Damar1, Recep Eroz2

  • 1Duzce University, Faculty of Medicine, Department of Cardiology, Duzce, Turkey.

Medeniyet Medical Journal
|March 15, 2021
PubMed

Insights

Certain inherited thrombophilia gene variations are linked to ST-elevation myocardial infarction (STEMI). These genetic factors, including MTHFR A1298C and Factor XIII (V34L), may play a role in STEMI development and could inform future prevention strategies.

Area of Science:

  • Cardiovascular Genetics
  • Thrombophilia Research
  • Molecular Cardiology

Background:

  • ST-elevation myocardial infarction (STEMI) is a critical manifestation of coronary artery disease, often linked to thrombotic events.
  • Understanding the genetic predispositions, particularly inherited thrombophilia, is crucial for identifying individuals at higher risk.

Purpose of the Study:

  • To investigate the association between various inherited thrombophilia gene variants and the occurrence of STEMI.
  • To compare the prevalence of these genetic factors in STEMI patients versus a control group.

Main Methods:

  • A case-control study involving 53 STEMI patients and 47 controls.
  • Genetic analysis of thrombophilia-associated genes including FactorV, MTHFR, FactorII, Factor XIII, PAI-1, and others.
  • Echocardiography and assessment of traditional cardiovascular risk factors.

Main Results:

  • Significant associations were found between STEMI and MTHFR A1298C, Factor XIII (V34L), ITGB, and ACE gene variations.
  • Specific gene variations showed increased prevalence in STEMI patients with comorbidities like smoking, hypertension, and family history of heart disease.

Conclusions:

  • Inherited thrombophilia gene variants are significantly associated with STEMI.
  • These genetic factors hold potential for the prevention and management of STEMI, warranting further investigation in larger cohorts.
Abstract

Keywords:
Coronary artery diseaseSTEMIhypercoagulationinherited thrombophiliathrombosis

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