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Updated: Nov 13, 2025

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Atypical Hemolytic Uremic Syndrome: Cancer-Induced or Chemotherapy-Induced?

Ashish Sethi1, Raj Moses2

  • 1Internal Medicine, Allegheny Health Network, Pittsburgh, USA.

Cureus
|March 15, 2021
PubMed

Atypical hemolytic uremic syndrome (aHUS) is an atypical type of thrombotic microangiopathy (TMA), which is characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and thrombi in small blood vessels, leading to end-organ damage. aHUS causes an over-activation of the complement pathway. There are many etiologies of aHUS, including inherited and acquired. This condition has a high mortality rate, as it is often detected late in the disease course. Eculizumab, an inhibitor of the terminal complement pathway, needs to be prescribed as soon as the diagnosis is confirmed. There is limited evidence, however, regarding the duration of treatment. Therefore, it is vital to conduct further analysis on other alternatives and pharmacokinetics with this type of complement inhibitor.

Keywords:
atypical hemolytic uremic syndromecomplementeculizumabgemcitabinegemcitabine-induced hemolytic uremic syndromehemolytic uremic syndromepancreas cancerparoxysmal nocturnal hemoglobinuria (pnh)ravulizumabthrombotic microangiopathy

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