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Updated: Nov 13, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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miRNAs Flowing Up and Down: The Concerto of Psoriasis

Yang Xiuli1, Wang Honglin1

  • 1Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Translational Medicine Center, Shanghai Institute of Immunology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Medicine
|March 15, 2021
PubMed

Insights

Dysregulated microRNAs (miRNAs) contribute to psoriasis by affecting skin cell proliferation and immune cell balance. These molecular players, including miR-31 and miR-125b, are key targets for understanding and treating this chronic skin condition.

Area of Science:

  • Dermatology
  • Immunology
  • Molecular Biology

Background:

  • Psoriasis is a chronic immune-mediated skin disease.
  • Hallmarks include keratinocyte hyperproliferation and CD4+ T cell imbalance.
  • Dysregulated microRNAs (miRNAs) are implicated in psoriasis pathogenesis.

Purpose of the Study:

  • To review dysregulated miRNAs contributing to psoriasis hallmarks.
  • To focus on confirmed miRNA target genes.
  • To explore miRNA roles in keratinocyte and T cell functions.

Main Methods:

  • Literature review of studies on miRNAs in psoriasis.
  • Analysis of miRNA networks and their target genes.
  • Focus on specific upregulated and downregulated miRNAs.

Main Results:

  • Upregulated miRNAs (miR-31, miR-203, miR-155, miR-21) and downregulated miRNAs (miR-99a, miR-125b) affect keratinocyte proliferation and differentiation.
  • Upregulated miR-210 and downregulated miR-138 impact CD4+ T cell subset balance.
  • These miRNAs regulate key transcription factors like NF-κB and STAT3.

Conclusions:

  • Dysregulated miRNAs, both up and down, collaborate in psoriasis development and maintenance.
  • Targeting these miRNAs offers potential therapeutic strategies for psoriasis.
  • Understanding miRNA networks is crucial for unraveling psoriasis mechanisms.
Keywords:
CD4+ T cellsepidermal hyperplasiakeratinocytesmiRNAspsoriasis

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