Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination
Areum Park1,2, Kyu-Sung Jeong2, Hyuk Lee1,3
1Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
Abstract:
We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.
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