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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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Opium as a carcinogen: A systematic review and meta-analysis
Mohammad Zamiri Bidary1,2,3, Mehrdad Sahranavard2,4, Arash Akhavan Rezayat1
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Eclinicalmedicine
|March 15, 2021
Summary
Opium consumption significantly increases cancer risk, particularly for respiratory and head and neck cancers. This meta-analysis confirms a strong association between opium use and various malignancies.
Area of Science:
- Oncology
- Epidemiology
- Toxicology
Background:
- Previous studies on opium and cancer risk yielded controversial results.
- A lack of consensus necessitated a comprehensive review of existing evidence.
Purpose of the Study:
- To systematically review and meta-analyze the association between opium consumption and cancer.
- To quantify the cumulative risk of developing various cancers due to opium use.
Main Methods:
- Searched four major electronic databases (ISI Web of Science, PubMed, Scopus, Embase) and two regional databases (Magiran, SID).
- Appraised 34 studies (18,230 individuals) using the Newcastle Ottawa Scale (NOS).
- Pooled Odds Ratios (OR) using Comprehensive Meta-analysis (CMA) with random effects models.
Main Results:
- Opium consumption was linked to a significantly increased rate of malignancies (OR = 4.35; 95% CI = 3.36-5.62).
- Subgroup analysis revealed heightened risks for larynx (OR = 9.58), respiratory (OR = 9.02), head and neck (OR = 8.03), and colon cancers (OR = 5.58).
Conclusions:
- Opium consumption is strongly associated with an increased risk of all reported cancer types.
- Further research into the underlying pathophysiology of opium-induced carcinogenesis is warranted.
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