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Recent progress in the treatment of non-systemic juvenile idiopathic arthritis

John M Bridges1, Elizabeth D Mellins2, Randy Q Cron1

  • 1Children's of Alabama/University of Alabama at Birmingham, Birmingham, Alabama, USA.

Faculty Reviews
|March 15, 2021
PubMed

Insights

Juvenile idiopathic arthritis (JIA) is a chronic childhood disease. This review covers new JIA treatments, focusing on personalized medicine and biologic modifiers for better patient outcomes.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Inflammatory Diseases

Background:

  • Juvenile idiopathic arthritis (JIA) affects 1 in 1,000 children.
  • Diverse JIA categories complicate literature interpretation.
  • Chronic inflammation impacts joints and other organs.

Purpose of the Study:

  • Review recent advancements in understanding and treating non-systemic JIA.
  • Highlight progress in personalized JIA treatment strategies.
  • Discuss challenges in managing JIA-related uveitis and temporomandibular joint issues.

Main Methods:

  • Literature review of recent developments in JIA.
  • Analysis of current biologic modifiers for JIA treatment.
  • Examination of challenging JIA manifestations and treatment guidelines.

Main Results:

  • New insights into non-systemic JIA pathogenesis and management.
  • Biologic therapies offer personalized treatment options for JIA.
  • Uveitis and TMJ involvement present significant therapeutic hurdles.

Conclusions:

  • Personalized medicine is advancing JIA treatment.
  • Current guidelines support literature-guided JIA management.
  • Ongoing research is crucial for optimizing JIA care.

Keywords:
DMARDJuvenile idiopathic arthritisbiologictemporomandibular jointuveitis

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