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VCP/p97 modulates PtdIns3P production and autophagy initiation.

Lidia Wrobel1,2, Sandra M Hill1,2,3, Avraham Ashkenazi1,2

  • 1Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK.

Autophagy
|March 15, 2021
PubMed
Summary

Valosin-containing protein (VCP) is crucial for cellular quality control and neurodegenerative disease. VCP regulates autophagy by controlling phosphatidylinositol-3-phosphate (PtdIns3P) levels and promoting autophagosome biogenesis.

Keywords:
ATXN3PI(3)PPI3KVCP/p97autophagy initiationbeclin 1

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