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Related Experiment Video

Updated: Nov 12, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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Reframing Recruitment: Evaluating Framing in Authorization for Research Contact Programs.

Candace D Speight1, Charlie Gregor2, Yi-An Ko3

  • 1Emory University, School of Medicine, Atlanta, Georgia, USA.

AJOB Empirical Bioethics
|March 15, 2021
PubMed
Summary
This summary is machine-generated.

Positive communication strategies, like using graphics, can increase patient willingness to authorize research contact. While comprehension didn't change, enrollment likelihood improved, suggesting effective recruitment tactics.

Keywords:
Informed consentclinical researchelectronic health recordsrecruitmentresearch ethicssurvey

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Area of Science:

  • Clinical research operations
  • Behavioral science in healthcare
  • Patient recruitment strategies

Background:

  • The clinical research landscape presents recruitment challenges and opportunities.
  • Electronic health record review enables identification and direct contact of eligible patients.
  • Behavioral science principles can influence patient authorization and understanding of research programs.

Purpose of the Study:

  • To evaluate the impact of behavioral science-driven communication on patient authorization for research contact.
  • To assess the effect of different flyer designs (neutral, positive text, positive graphics) on enrollment likelihood and comprehension.

Main Methods:

  • An online survey with 1070 participants from a nationally-representative sample.
  • Random assignment to view one of three flyers: neutral, positive text, or positive graphics.
  • Primary outcomes measured: likelihood of enrollment and program comprehension; analyzed using Chi-Square tests and regression.

Main Results:

  • The positive graphics flyer significantly increased the likelihood of enrollment compared to the neutral flyer (28.7% vs. 19.0%, p=0.002).
  • Both positive text and graphics flyers showed increased odds of hypothetical enrollment after adjustment (OR=1.55, OR=1.95).
  • Flyer type did not significantly impact overall comprehension (p=0.21); higher enrollment likelihood correlated with better comprehension.

Conclusions:

  • Behavioral science-driven communication impacts hypothetical enrollment likelihood but not comprehension.
  • Simple, positive language and visual aids may be effective and ethically sound for research recruitment.
  • Further research is needed to optimize recruitment strategies using these approaches.