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Research Priorities for Patients with Heart Failure and Central Sleep Apnea. An Official American Thoracic Society

Jeremy E Orr, Indu Ayappa, Danny J Eckert

    American Journal of Respiratory and Critical Care Medicine
    |March 15, 2021
    PubMed

    Insights

    Future research is needed to improve outcomes for central sleep apnea (CSA) in heart failure patients. Key priorities include understanding CSA pathophysiology, treatment impacts, and implementation strategies.

    Area of Science:

    • Sleep Medicine
    • Cardiology
    • Pulmonary Medicine

    Background:

    • Central sleep apnea (CSA) is prevalent in heart failure patients, associated with poor outcomes.
    • Current progress in improving outcomes for these patients remains limited.

    Purpose of the Study:

    • To identify and prioritize key research areas for central sleep apnea (CSA) in heart failure.
    • To guide future research efforts to advance patient care.

    Main Methods:

    • Convened an international, multidisciplinary expert workgroup.
    • Conducted discussions at the American Thoracic Society 2019 International Conference.
    • Authored a statement based on group consensus.

    Main Results:

    • Identified 11 specific research priorities for CSA in heart failure.
    • Priorities span pathophysiology, individual variability, outcome assessment techniques, treatment efficacy (device and pharmacologic), and treatment implementation.
    • Key areas include breathing control, CSA pathogenesis, and patient-centered outcomes.

    Conclusions:

    • Advancing care for heart failure patients with CSA requires progress in translational, epidemiological, and patient-centered outcome research.
    • Targeted research is crucial given the rising prevalence of heart failure and its significant burden.
    • Improving knowledge of CSA pathogenesis and treatment is a priority.

    Keywords:
    heart failurerespirationsleep apnea

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