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Thromboembolic Complications in Severe COVID-19: Current Antithrombotic Strategies and Future Perspectives

Juan J Rodriguez1, Oscar C Munoz2, Mateo Porres-Aguilar3

  • 1Facultad de Medicina, Universidad Autonoma Bucaramanga, Bucaramanga, Colombia.

Cardiovascular & Hematological Disorders Drug Targets
|March 15, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) increases the risk of dangerous blood clots in both veins and arteries. This review covers COVID-19

Area of Science:

  • Cardiology
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19, caused by SARS-CoV-2, is a global pandemic.
  • A significant characteristic of COVID-19 is its association with thrombotic events.
  • Thromboembolism can affect both venous and arterial circulation in patients with COVID-19.

Purpose of the Study:

  • To review arterial and venous thromboembolic complications in COVID-19 patients.
  • To discuss the epidemiology and pathogenesis of these complications.
  • To summarize current antithrombotic strategies and future research directions.

Main Methods:

  • Literature review of studies on COVID-19 and thromboembolism.
  • Analysis of epidemiological data and pathogenetic mechanisms.
  • Evaluation of hematologic biomarkers and antithrombotic treatments.

Main Results:

  • COVID-19 patients exhibit increased risk of both arterial and venous thromboembolism.
  • Specific hematologic biomarkers are associated with thrombotic risk.
  • Current antithrombotic strategies are being evaluated for optimal use.

Conclusions:

  • Thromboembolic complications are a major concern in COVID-19.
  • Further research and clinical trials are needed to establish definitive thromboprophylaxis guidelines.
  • Optimizing antithrombotic strategies is crucial for managing severe COVID-19.

Keywords:
COVID-19bleedingmyocardial infarctionpulmonary embolism.strokethromboembolismthromboprophylaxisthrombosisvenous thromboembolism

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