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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
Circulating miRNA in Atherosclerosis: A Clinical Biomarker and Early Diagnostic Tool
Ashish Ranjan Sharma1, Garima Sharma2, Manojit Bhattacharya3
1Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-Do, 24252, Republic of Korea.
Abstract:
Atherosclerosis, a vascular disease, is characterized by narrowing the arteries and forming plaque inside arteries. There is a record of 17.5 million associated deaths recorded annually, representing 31% of global death. It has been noted that there is an association between vascular fibrosis and atherosclerosis. The thickening of the arterial wall and reduction of the lumen diameter may cause unwarranted deposition of extracellular matrix (ECM), and these conditions help in the progression of many clinical diseases and pathological conditions, such as atherosclerosis. Here, we reviewed the involvement of various circulating microRNAs (miRNAs) in the very early diagnosis of atherosclerosis. We have also tried to provide an insight into the advantages and validation of circulating miRNAs through different techniques. We have discussed different circulating miRNAs, such as miR-17, miR-17-5p, miR-29b, miR-30, miR-92a, miR-126, miR-143, miR-145, miR-146a, miR-212, miR-218, miR-221, miR-222 and miR- 361-5p as a biomarker for clinical diagnosis of atherosclerosis. The insightful demonstration in this review will offer a better opportunity for the researchers and technology developers in understanding the current scenario of circulating miRNA, which could facilitate them in improving the current diagnostic technologies of atherosclerosis in clinics.
Insights
Circulating microRNAs (miRNAs) show promise for early atherosclerosis diagnosis. This review highlights specific miRNAs as potential biomarkers to improve clinical detection of this common vascular disease.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Molecular Diagnostics
Background:
- Atherosclerosis is a leading cause of global mortality, characterized by arterial plaque buildup and narrowing.
- Vascular fibrosis and extracellular matrix deposition contribute to atherosclerosis progression and related pathologies.
- Early diagnosis is crucial for managing atherosclerosis and reducing its significant health impact.
Purpose of the Study:
- To review the role of circulating microRNAs (miRNAs) in the early diagnosis of atherosclerosis.
- To explore the advantages and validation methods for using circulating miRNAs as diagnostic biomarkers.
- To identify specific miRNAs with potential as early diagnostic markers for atherosclerosis.
Main Methods:
- Literature review focusing on circulating microRNAs (miRNAs) and atherosclerosis.
- Analysis of studies investigating miRNA expression patterns in atherosclerosis.
- Examination of techniques for validating circulating miRNAs as biomarkers.
Main Results:
- Several circulating microRNAs (miRNAs), including miR-17, miR-29b, miR-126, miR-143, and miR-145, are associated with atherosclerosis.
- These miRNAs demonstrate potential as early diagnostic biomarkers for atherosclerosis.
- Various techniques exist for the validation of circulating miRNAs.
Conclusions:
- Circulating microRNAs (miRNAs) offer a promising avenue for the early clinical diagnosis of atherosclerosis.
- Specific miRNAs can serve as valuable biomarkers for detecting atherosclerosis at its nascent stages.
- Further research and technological development in circulating miRNA analysis can enhance atherosclerosis diagnostics.
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