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Updated: Nov 12, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
765
Emerging systemic antitarget treatment for differentiated thyroid carcinoma.
Neus Basté1,2, Mireia Mora3,4,5, Juan José Grau1,5
1Medical Oncology Department, Hospital Clinic Barcelona.
Current Opinion in Oncology
|March 15, 2021
Summary
New targeted therapies, including neurotrophic tyrosine kinase receptor (NTRK) and rearranged during transfection (RET) inhibitors, offer improved safety profiles for differentiated thyroid carcinoma. Molecular profiling is crucial for accessing these precision medicines.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Differentiated thyroid carcinoma (DTC) treatment has evolved significantly.
- Kinase inhibitors are standard but have adverse effects.
- New targeted therapies show promise with better safety.
Purpose of the Study:
- To review novel systemic treatment strategies for DTC.
- To discuss advancements in understanding DTC molecular biology.
- To highlight the role of molecular profiling in precision medicine.
Main Methods:
- Review of recent clinical trials and scientific literature.
- Analysis of emerging targeted therapies for DTC.
- Evaluation of molecular profiling techniques and their impact.
Main Results:
- NTRK and RET inhibitors represent significant advancements for specific DTC subtypes.
- Newer agents demonstrate improved safety and efficacy.
- Clinical trials are exploring further novel strategies.
Conclusions:
- Precision medicine is becoming central to DTC management.
- Molecular characterization is essential for treatment selection.
- Access to diagnostic tools and targeted therapies is critical.
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