Determination of cefpirome (HR 810) in serum and urine

Cefpirome (HR 810) is a new cephalosporin under clinical investigation. Specific and sensitive HPLC- and agar-diffusion methods were developed for the determination of serum- and urine concentrations. The methods are fully validated according to the IFCC Recommendations on Quality Control in Clinical Chemistry. In order to demonstrate the usefulness of both methods, pharmacokinetic profiles of cefpirome after 1 g i.v. administration to human volunteers are presented.