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Clindamycin for colonization and infection by methicillin-resistant Staphylococcus aureus
1Microbiology Section, Veterans Administration Medical Center, East Orange, New Jersey 07019.
Infection
|March 1, 1988
Summary
Effective treatment options for methicillin-resistant Staphylococcus aureus (MRSA) are limited. Clindamycin successfully eradicated MRSA in five patients, including one with a persistent infection during vancomycin therapy, suggesting its potential as an alternative treatment.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Limited effective antimicrobial therapies exist for methicillin-resistant Staphylococcus aureus (MRSA) infections and colonization.
- In vitro studies indicate that many MRSA strains remain susceptible to clindamycin.
Observation:
- This study reports on five patients with varying severity of MRSA colonization or infection.
- One patient experienced a persistent MRSA infection despite vancomycin treatment.
Findings:
- Clindamycin therapy successfully eradicated MRSA in all five reported patients.
- Clindamycin was effective in clearing the persistent MRSA infection in the patient previously treated with vancomycin.
Implications:
- Clindamycin demonstrates potential as an effective alternative antimicrobial agent for MRSA.
- Further consideration of clindamycin is warranted for managing MRSA colonization and infection.