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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Nov 12, 2025

Diffusion Imaging in the Rat Cervical Spinal Cord

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion-prepared fast spin echo for artifact-free spinal cord imaging.

Seung-Yi Lee^1,2, Briana P Meyer^1,2, Shekar N Kurpad³

¹Neuroscience Doctoral Program, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Magnetic Resonance in Medicine

|March 15, 2021

Summary

This summary is machine-generated.

This study introduces a new diffusion MRI technique for rodent spinal cord injury, improving lesion detection. The method minimizes artifacts, enhancing contrast for better injury evaluation.

Keywords:

artifact reduction diffusion imaging motion preparation spinal cord

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Area of Science:

Biomedical Imaging
Neuroscience
Radiology

Background:

Diffusion MRI offers critical insights into acute neurological damage, particularly spinal cord injury.
Traditional diffusion-weighted imaging (DWI) using EPI readout in rodent spinal cords suffers from motion and susceptibility artifacts.
Diffusion filtering can enhance injury detection by mitigating edema effects in acute spinal cord injury.

Purpose of the Study:

To develop and validate a novel diffusion-prepared rapid acquisition with relaxation enhancement (RARE) sequence for sagittal imaging of the rodent spinal cord.
To minimize motion and susceptibility artifacts in diffusion MRI of acute spinal cord injury.
To improve the detection and characterization of spinal cord lesions.

Main Methods:

Utilized Sprague-Dawley rats with induced cervical contusion spinal cord injury at 9.4 Tesla.
Optimized the diffusion-prepared RARE sequence, including motion-compensated encoding, gating strategies, and diffusion-weighting schemes.
Evaluated artifact reduction and lesion-to-healthy tissue contrast compared to conventional DTI.

Main Results:

The diffusion-prepared RARE sequence produced high-quality sagittal images, free from susceptibility artifacts.
Second-order motion-compensated encoding and gating effectively reduced motion artifacts.
Axial diffusivity from the filtered diffusion-encoding scheme showed a 52% improvement in lesion-to-healthy tissue contrast over DTI's 25%.

Conclusions:

Demonstrated the feasibility of high-quality diffusion sagittal imaging in the rodent cervical spinal cord using diffusion-prepared RARE.
The developed sequence and findings are anticipated to enhance the detection and evaluation of acute spinal cord injuries.
This technique holds promise for advancing preclinical research in spinal cord injury.