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Updated: Nov 12, 2025

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
[Gastric acid suppression and antibiotic resistance; the role of a meta-analysis]
M J M Bonten1,2, C H van Werkhoven3
1UMC Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijnsgeneeskunde, Utrecht (tevens: afd. Medische Microbiologie).
Abstract:
We discuss a meta-analysis that reported on the association between gastric acid suppression and carriage with antibiotic resistant bacteria, with a special focus on the association for carriage with ESBL-producing Gram-negative bacteria in non-hospitalized subjects. Results from a recent population-based study (not included in the meta-analysis) were added to this subgroup of the meta-analysis. The data point to a positive, yet minor, association between gastric acid suppression and carriage with ESBL-producing Gram-negative bacteria in non-hospitalized subjects in the Netherlands.
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