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[Anemia as a risk factor of contrast-associated acute kidney injury]

O I Mironova1, A D Deev2, P G Lakotka1

  • 1Sechenov First Moscow State Medical University (Sechenov University).

Terapevticheskii Arkhiv
|March 15, 2021
PubMed

Insights

Anemia may increase the risk of contrast-associated acute kidney injury (CA-AKI) in patients with coronary artery disease. However, this study did not find a statistically significant link, suggesting further research is needed.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Contrast-associated acute kidney injury (CA-AKI) is a significant concern in patients undergoing procedures involving contrast media.
  • Anemia is a common comorbidity in patients with coronary artery disease (CAD).
  • The potential role of anemia as a risk factor for CA-AKI requires further investigation.

Purpose of the Study:

  • To evaluate the association between anemia and the incidence of CA-AKI in patients with stable coronary artery disease.
  • To determine if anemia is an independent risk factor for developing CA-AKI post-contrast administration.

Main Methods:

  • A prospective cohort study including 1023 patients with chronic coronary artery disease.
  • Anemia was present in 83 patients.
  • CA-AKI was defined by KDIGO criteria (≥25% or ≥0.5 mg/dl increase in serum creatinine within 48 hours post-contrast).

Main Results:

  • CA-AKI developed in 14.5% of patients with anemia based on relative creatinine increase.
  • CA-AKI prevalence was 2.4% based on absolute creatinine increase in anemic patients.
  • While the rate of CA-AKI was higher in anemic patients (14.4% vs. 12.7%), the difference was not statistically significant (p=0.61).

Conclusions:

  • The study observed a higher prevalence of CA-AKI in patients with anemia, but this finding did not reach statistical significance.
  • Further research with larger cohorts is warranted to definitively establish the role of anemia in CA-AKI development.
Abstract

Keywords:
anemiacontrastcontrast-associated acute kidney injurycontrast-induced acute kidney injurycontrast-induced nephropathycoronary angiographycoronary artery diseasepercutaneous coronary intervention

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