Related Experiment Video

Updated: Nov 12, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.2K

[The problem of global development of antibiotic resistant nosocomial pathogens]

N I Gabrielyan1, S О Sharapchenko1, О V Kisil2

  • 1Shumakov National Medical Research Center of Transplantology and Artificial Organs.

Terapevticheskii Arkhiv
|March 15, 2021
PubMed

Insights

Multidrug-resistant nosocomial infections pose a significant threat, especially in transplant patients. This study tracked carbapenem resistance in key pathogens, revealing a decrease in susceptible strains of Klebsiella and Acinetobacter.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Transplant Medicine

Background:

  • Rising antibiotic resistance limits treatment options for nosocomial infections.
  • Transplant recipients require lifelong immunosuppression, increasing susceptibility to severe infections.
  • Controlling multidrug-resistant pathogens is critical in healthcare settings.

Purpose of the Study:

  • To analyze the dynamics of carbapenem resistance in Klebsiella spp., Acinetobacter spp., Pseudomonas spp., and Staphylococcus spp.
  • To investigate pathogens isolated from organ transplant recipients between 2009 and 2019.
  • To understand resistance patterns for effective antimicrobial strategies.

Main Methods:

  • Retrospective analysis of bacterial isolates from blood cultures of organ recipients.
  • Monitoring carbapenem resistance trends over a decade (2009-2019).
  • Identification of specific pathogen species and their resistance profiles.

Main Results:

  • A significant annual decrease in carbapenem-sensitive strains of Klebsiella spp. was observed.
  • A significant annual decrease in carbapenem-sensitive strains of Acinetobacter spp. was observed.
  • Trends for Pseudomonas spp. and Staphylococcus spp. resistance were also analyzed.

Conclusions:

  • Understanding institutional pathogen resistance profiles is crucial for antimicrobial stewardship.
  • Monitoring resistance dynamics aids in developing effective strategies against multidrug-resistant organisms.
  • This data can serve as a predictive tool for infection control in transplant centers.
Keywords:
AcinetobacterKlebsiellaPseudomonasStaphylococcusThe problem of global expansion of multidrug-resistant nosocomial infections pathogens is under special attention at the moment. Antibiotic resistance increasing give us the limited treatment options. This problem is particularly acute for transplant clinics, because of patients need lifelong immunosuppressive therapy. From the one hand this ensures stable allograft functioning, but from the other – increases the risk of severe infectious complications in the postoperative period. The purpose of this article is analysis carbapenem resistance dynamics of Klebsiella spp., Acinetobacter spp., Pseudomonas spp. and Staphylococcus spp. isolated from the blood of recipients of donor organs from 2009 to 2019 in the Shumakov National Medical Research Center of Transplantology and Artificial Organs. A significant annual decrease of carbapenem-sensitive strains of Klebsiella spp. and Acinetobacter spp. are shown. The study of a distinctive pathogen resistance profile specific to each institution can help one in selecting an adequate antimicrobial strategy and is an effective predictive tool for controlling the growth of multidrug-resistant microorganisms. antibiotic resistancecarbapenemsepidemiological surveillancenosocomial infectionsorgan transplantation

More Related Videos

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.1K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

2.3K

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
774
Antibiotic Selection00:57

Antibiotic Selection

Overview
57.1K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.1K
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
9.8K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.8K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
208