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Upper Respiratory Drugs: Decongestants01:27

Upper Respiratory Drugs: Decongestants

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Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
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Acute Pharyngitis01:30

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Updated: Nov 12, 2025

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
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[Herbal medicine for acute sinusitis - current trends].

E V Nosulya1, I A Kim2,3, M A Yushkina1,3

  • 1Research Clinical Institute of Otorinolaryngology named after. L.I. Sverzhevsky, Moscow, Russia.

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|March 15, 2021
PubMed
Summary

Pelargonium sidoides (EPs 7630) extract effectively reduces acute sinusitis symptoms and duration. This herbal remedy is a safe and valuable addition to treatment protocols for acute respiratory infections.

Keywords:
Pelargonium sidoidescoldsepidemiology of acute sinusitisherbal remediesmodern treatment of acute sinusitis

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Area of Science:

  • Pharmacology
  • Phytomedicine
  • Infectious Diseases

Background:

  • Acute sinusitis is a common condition often treated with various therapeutic approaches.
  • Herbal remedies are increasingly explored for their efficacy and safety in managing respiratory infections.
  • Pelargonium sidoides, specifically its root extract (EPs 7630), has shown potential in treating upper respiratory tract infections.

Purpose of the Study:

  • To review and summarize the role of herbal remedies, particularly Pelargonium sidoides extract (EPs 7630), in treating acute sinusitis.
  • To evaluate the available data on the efficacy and safety of EPs 7630 for acute sinusitis management.

Main Methods:

  • A systematic review of scientific literature was conducted.
  • Databases searched included Cochrane Library, RSCI, MEDLINE, and PubMed.
  • Keywords focused on acute sinusitis epidemiology, treatment, colds, and Pelargonium sidoides.

Main Results:

  • Clinical trial data indicate EPs 7630 significantly outperforms placebo in alleviating symptoms of acute respiratory infections.
  • The extract demonstrates a notable reduction in both the duration and severity of illness.
  • EPs 7630 exhibits a high safety profile, making it a clinically significant option.

Conclusions:

  • Pelargonium sidoides extract (EPs 7630) is advisable for inclusion in acute sinusitis (OS) treatment protocols.
  • The demonstrated efficacy and safety profile position EPs 7630 as a key component in the drug therapy for acute sinusitis.