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[Familial prostate cancer and genetic predisposition]
V H Meissner1, M Jahnen1, K Herkommer2
1Klinik und Poliklinik für Urologie, Universitätsklinikum rechts der Isar, Fakultät für Medizin, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland.
Der Urologe. Ausg. A
|March 15, 2021
Summary
Familial prostate cancer, linked to genetic predisposition, occurs more frequently and is diagnosed earlier than sporadic cases. Individuals with germline mutations may require more intensive treatment for aggressive disease.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Twenty percent of prostate cancer patients have a positive family history.
- A subset of these patients exhibit a genetic predisposition to prostate cancer.
Purpose of the Study:
- To analyze the incidence, diagnosis, and clinical course of familial versus sporadic prostate cancer.
- To investigate the role of genetic predisposition in prostate cancer.
Main Methods:
- Literature search and analysis of studies.
- Utilized PubMed and Embase databases.
Main Results:
- Familial prostate cancer incidence is higher and diagnosis age is lower compared to sporadic cases.
- Prostate cancer risk is influenced by the number, relationship degree, and age of onset of affected family members.
- Germline mutations necessitate more intensive therapy due to a more aggressive disease course.
Conclusions:
- Detailed family history and pedigree analysis are crucial for risk assessment.
- Genetic counseling and annual prostate-specific antigen (PSA) screening from age 40 are recommended for high-risk families.
- Germline mutation verification indicates a need for more intensive treatment strategies.
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