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Potential liquid crystal-based biosensor depending on the interaction between liquid crystals and proteins.

Priyanki Kalita1, Shashank Sekhar Shukla2, Ranjan K Singh2

  • 1Department of Physics, National Institute of Technology, Shillong-793003, Meghalaya, India.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|March 15, 2021
PubMed
Summary

This study demonstrates a novel liquid crystal biosensor for detecting Human serum albumin protein. The biosensor utilizes molecular interactions to provide an effective and early detection method for this important biomarker.

Keywords:
AlignmentConfigurationLiquid crystal 5CBMolecular dockingProtein human serum albuminRaman spectrapolarizing optical microscopy (POM)

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Area of Science:

  • Biomolecular detection
  • Materials science
  • Chemical sensing

Background:

  • Liquid crystal biosensors offer a simple and effective platform for detecting biomolecules and chemical events.
  • Early detection of biomarkers like Human serum albumin (HSA) is crucial in various diagnostic applications.

Purpose of the Study:

  • To investigate the detection of Human serum albumin (HSA) protein using a room-temperature liquid crystal (LC) biosensor.
  • To elucidate the interaction dynamics between the LC molecule (4-pentyl-4-biphenylcarbonitrile) and HSA.

Main Methods:

  • Utilized a combination of Polarizing Optical Microscopy (POM), Raman Spectroscopy, and Molecular Docking.
  • POM was employed to observe changes in LC alignment during the nematic phase.
  • Raman Spectroscopy analyzed spectral changes with temperature, while docking predicted binding interactions.

Main Results:

  • Observed distinct changes in the alignment of LC molecules in the presence of HSA under POM.
  • Molecular docking revealed specific binding interactions and identified key amino acid residues involved.
  • Temperature-dependent Raman spectroscopy showed spectral shifts correlating with docking findings.

Conclusions:

  • The study successfully demonstrates the capability of the LC biosensor for HSA detection.
  • The combined techniques provide a comprehensive understanding of the LC-protein interaction mechanism.
  • This approach offers a promising avenue for developing sensitive and specific biosensing tools.