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Related Experiment Video

Updated: Nov 12, 2025

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Initial 3D Cell Cluster Control in a Hybrid Gel Cube Device for Repeatable Pattern Formations

Published on: March 21, 2019

2D printed multicellular devices performing digital and analogue computation.

Sira Mogas-Díez¹, Eva Gonzalez-Flo¹, Javier Macía²

¹Synthetic Biology for Biomedical Applications Lab, Department of Experimental and Health Sciences. Universitat Pompeu Fabra, Biomedical Research Park, Barcelona, Spain.

Nature Communications

|March 16, 2021

Summary

This summary is machine-generated.

Researchers developed a new method for creating printable cellular devices using biological signals on a 2D surface. This breakthrough enables the reliable industrial production of digital and analogue cellular circuits for diverse applications.

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Area of Science:

Synthetic Biology
Bio-computation

Background:

Significant efforts have been made to develop cellular computational devices.
Current limitations hinder the technological transfer and development of lab-based applications.

Purpose of the Study:

To propose a methodology for constructing printable cellular devices (digital or analogue) for various applications.
To enable the development of end-user applications beyond laboratory settings.

Main Methods:

Developed a methodology for printable cellular devices operating on a 2D surface.
Utilized a biological signal (carrying signal) diffused across the surface to encode circuit information.
Designed device components spatially arranged to modulate the carrying signal based on external inputs.
Validated the methodology by printing 2D cellular circuits on paper using cellular inks.

Main Results:

Successfully printed and analyzed both digital and analogue cellular circuits.
Demonstrated the feasibility of using a single set of cellular inks with varying spatial topologies.
Validated the concept of computation through signal diffusion and modulation on a 2D surface.

Conclusions:

The proposed methodology offers a feasible and reliable approach for industrial production of cellular circuits.
This work paves the way for diverse applications of printable bio-computational devices.
Enables the creation of end-user applications by overcoming current technological restraints.