Related Experiment Video

Updated: Nov 12, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.1K

Fungal Dysbiosis in Children with Celiac Disease

Mohammad El Mouzan1, Abdulrahman Al-Hussaini2, Brian Fanelli3

  • 1Department of Pediatrics (Gastroenterology), King Saud University, P O Box 2925, Riyadh, 11461, Saudi Arabia. melmouzan@ksu.edu.sa.

Digestive Diseases and Sciences
|March 16, 2021
PubMed
Abstract

Insights

Children with new-onset celiac disease (CeD) show altered gut fungi, indicating potential fungal dysbiosis. This suggests fungi may play a role in the development of CeD in children.

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiome Research

Background:

  • Intestinal fungi interact with the immune system.
  • The link between gut fungi and childhood celiac disease (CeD) is understudied.
  • CeD is an immune-mediated condition affecting the small intestine.

Purpose of the Study:

  • To characterize the gut fungal microbiota in children with newly diagnosed CeD.
  • To compare fungal profiles between children with CeD and healthy controls.

Main Methods:

  • Metagenomics analysis of mucosal and fecal samples from children with CeD and controls.
  • Illumina HiSeq sequencing for fungal microbiota community analysis.
  • Bioinformatic analysis including diversity metrics (Shannon, PCoA) and differential abundance testing (DESeq).

Main Results:

  • Fungal dysbiosis observed in children with CeD.
  • Increased abundance of taxa such as Tricholomataceae, Saccharomyces cerevisiae, and Candida in CeD patients.
  • Decreased abundance of Pichia kudriavzevii and Pneumocystis jirovecii in CeD patients.
  • No significant difference in alpha diversity; distinct separation between mucosal and fecal fungal communities.

Conclusions:

  • Gut fungal dysbiosis is associated with new-onset childhood celiac disease.
  • Fungi may contribute to the pathogenesis of CeD.
  • Further longitudinal studies are required to confirm these findings and elucidate the functional role of fungi in CeD.
Keywords:
Celiac diseaseDysbiosisFungiMicrobiotaSaudi children

More Related Videos

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.4K
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

5.6K

Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
242
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
493
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.2K
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
512
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
532
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
620