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Dihydromyricetin Exhibits Antitumor Activity in Nasopharyngeal Cancer Cell Through Antagonizing Wnt/β-catenin

Ling Ye1, Gendi Yin2, Miaohua Jiang1

  • 1The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Integrative Cancer Therapies
|March 16, 2021
PubMed
Abstract

Insights

Dihydromyricetin (DMY) enhances cisplatin efficacy and reduces cancer stem cell properties in nasopharyngeal cancer. This natural flavonoid blocks the Wnt/β-catenin pathway, offering potential as a novel therapeutic agent.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer stem cells (CSCs) drive nasopharyngeal cancer progression and multidrug resistance.
  • The Wnt/β-catenin signaling pathway is implicated in chemoresistance and CSC maintenance.
  • Nasopharyngeal cancer (NPC) poses a significant therapeutic challenge due to resistance mechanisms.

Purpose of the Study:

  • To investigate the effects of dihydromyricetin (DMY) on cisplatin resistance in nasopharyngeal cancer.
  • To evaluate DMY's impact on cancer stem cell properties in nasopharyngeal cancer.
  • To elucidate the role of DMY in modulating the Wnt/β-catenin signaling pathway in nasopharyngeal cancer.

Main Methods:

  • In vitro and in vivo studies were conducted to assess DMY's functional role in nasopharyngeal cancer progression.
  • Cellular assays evaluated colony and tumor-sphere formation to assess stem cell properties.
  • Western blotting and xenograft models were used to analyze pathway modulation and in vivo efficacy.

Main Results:

  • DMY enhanced the growth inhibitory effects of cisplatin in resistant nasopharyngeal cancer cell lines.
  • DMY significantly reduced stem cell characteristics, including colony and tumor-sphere formation.
  • DMY administration inhibited tumor xenograft growth and modulated the Wnt/β-catenin signaling pathway.

Conclusions:

  • DMY exhibits anti-tumor activity in nasopharyngeal cancer by inhibiting the Wnt/β-catenin signaling pathway.
  • DMY effectively diminishes cancer stem cell properties and enhances chemosensitivity.
  • Dihydromyricetin represents a promising therapeutic candidate for nasopharyngeal cancer treatment.
Keywords:
Wnt/β-catenin signalingcancer stem celldihydromyricetinnasopharyngeal cancer

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