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Updated: Nov 12, 2025

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
Published on: May 23, 2018
Advances in single-cell whole genome sequencing technology and its application in biomedicine
Wang Zhuo1, Shen Xiaohan1, Shi Qihui1
1Institutes of Biomedical Sciences, Fudan University, Shanghai 201100, China.
Abstract:
The advent and development of single-cell whole-genome sequencing (scWGS) technology has shed lights on the genomic heterogeneities within biosamples at the single-cell resolution. The technology is particularly well-established in the recent decade and witnesses a variety of clinical applications, such as circulating tumor cell (CTC) detection and preimplantation genetic diagnosis/screening (PGD/PGS). In this review, we summarize the latest practical breakthroughs of scWGS in the field of biomedicine, with the hope of providing a guideline to apply single-cell genomic sequencing in clinical researches.
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