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Updated: Nov 12, 2025

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Rates of remission, sustained remission, and recurrence in a randomized controlled trial of cognitive behavioral
Hilary Weingarden1, Susanne S Hoeppner1, Ivar Snorrason1
1Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts, USA.
Background:
Little data exist on remission rates following psychotherapy for body dysmorphic disorder (BDD).
Methods:
Using data from a large study of therapist-delivered cognitive behavior therapy (CBT) versus supportive psychotherapy (SPT) for BDD (N = 120), we estimated remission rates at treatment endpoint, and rates of delayed remission, sustained remission, and recurrence at 6-month follow-up. We also examined improvement in broader mental health outcomes among remitters.
Results:
Full or partial remission rates at end-of-treatment were significantly higher following CBT (68%) than SPT (42%). At 6-month follow-up, an additional 10% (CBT) and 14% (SPT) experienced delayed remission, 52% (CBT) and 27% (SPT) experienced sustained remission, and 20% (CBT) and 14% (SPT) experienced recurrence. Remission was never achieved by 18% (CBT) and 45% (SPT). Participants in remission at end-of-treatment experienced significant improvements in functional impairment, depression severity, BDD-related insight, and quality of life compared to nonremitters.
Conclusions:
Full or partial remission rates are high following CBT for BDD and higher than after SPT.
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