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Nanoparticle-Based Activatable Probes for Bioimaging.
Tiancong Ma1,2, Tian Xia1
1Division of Nanomedicine, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1772, USA.
Advanced Biology
|March 16, 2021
Summary
Activatable nanoprobes enhance molecular imaging by responding to physiological cues. This review covers advances and challenges in translating these nanoparticle-based probes for clinical use.
Area of Science:
- Nanotechnology
- Molecular Imaging
- Biomedical Engineering
Background:
- Molecular imaging offers noninvasive in vivo functional and molecular insights at cellular levels.
- Activatable nanoprobes are designed to respond to specific physiological environments or biomarkers, enhancing imaging.
- Stimuli for these probes include redox status, pH, enzyme presence, and hypoxia.
Purpose of the Study:
- To critically review recent advancements in nanoparticle-based activatable imaging probes.
- To discuss the challenges hindering the clinical translation of these nanoprobes.
Main Methods:
- Literature review of nanoparticle-based activatable imaging probes.
- Analysis of probe design strategies responding to physiological parameters.
- Evaluation of clinical translation barriers.
Main Results:
- Nanoparticle-based activatable probes show promise for improved imaging efficacy, specificity, and sensitivity.
- Various physiological parameters can be utilized as triggers for probe activation.
- Significant challenges remain in the clinical translation of these advanced imaging agents.
Conclusions:
- Activatable nanoprobes represent a significant advancement in molecular imaging.
- Overcoming challenges in clinical translation is crucial for realizing the full potential of these nanoprobes.
