Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crossover Experiments01:16

Crossover Experiments

4.3K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.3K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

602
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
602
Study Design in Statistics01:15

Study Design in Statistics

9.7K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
9.7K
Experimental Designs01:16

Experimental Designs

16.3K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.3K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

68
Body:Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
68
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

73
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
73

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abnormal left ventricular subendocardial perfusion and diastolic function in women with obesity and heart failure and preserved ejection fraction.

The international journal of cardiovascular imaging·2023
Same author

QT Prolongation and In-Hospital Ventricular Arrhythmic Complications in Patients With Apical Ballooning Takotsubo Syndrome.

JACC. Clinical electrophysiology·2022
Same author

Contribution of hemoglobin concentration to cardiorespiratory fitness in black African American patients with recently decompensated heart failure and reduced ejection fraction.

Minerva cardiology and angiology·2022
Same author

Synergistic effect of myocardial injury and mid-regional proAdrenomedullin elevation in determining clinical outcomes of SARS-CoV-2 patients.

Frontiers in medicine·2022
Same author

Transition to rilonacept monotherapy from oral therapies in patients with recurrent pericarditis.

Heart (British Cardiac Society)·2022
Same author

Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications.

EBioMedicine·2022

Related Experiment Video

Updated: Nov 12, 2025

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.0K

Novel Trial Design: CHIEF-HF.

John A Spertus1, Mary C Birmingham2, Javed Butler3

  • 1Saint Luke's Mid America Heart Institute/University of Missouri-Kansas City (J.S., M.K.).

Circulation. Heart Failure
|March 16, 2021
PubMed
Summary
This summary is machine-generated.

This decentralized clinical trial is testing canagliflozin to reduce heart failure symptoms, using mobile technology for efficient, patient-centered evidence generation. The study aims to improve heart failure treatment outcomes cost-effectively.

Keywords:
COVID-19Kansas City Cardiomyopathy Questionnairecanagliflozincardiomyopathyheart failure

More Related Videos

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.9K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

874

Related Experiment Videos

Last Updated: Nov 12, 2025

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
04:24

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program

Published on: April 19, 2019

12.0K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.9K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

874

Area of Science:

  • Cardiology
  • Clinical Trials
  • Digital Health

Background:

  • High costs of clinical trials necessitate innovative strategies for evidence generation and novel therapy testing.
  • Decentralized, patient-centered clinical trials leverage mobile technologies to reduce reliance on in-person visits.
  • This approach aims to efficiently test canagliflozin for heart failure symptom reduction.

Purpose of the Study:

  • To test the efficacy of 12-week canagliflozin treatment in reducing heart failure symptoms.
  • To evaluate canagliflozin's impact regardless of ejection fraction or diabetes status.
  • To demonstrate a novel, cost-effective model for clinical trials using mobile technology.

Main Methods:

  • A decentralized, patient-centered randomized clinical trial enrolling 1900 patients with heart failure.
  • Stratification by ejection fraction (reduced ≤40% or preserved >40%) and 1:1 randomization to canagliflozin or placebo.
  • Primary outcome: 12-week change in Kansas City Cardiomyopathy Questionnaire total symptom score; secondary outcomes include daily step count.

Main Results:

  • The CHIEF-HF trial is currently enrolling participants.
  • Enrollment continues despite the COVID-19 pandemic.
  • This study provides real-time data on trial progress.

Conclusions:

  • CHIEF-HF employs a novel decentralized model to test canagliflozin for heart failure symptom improvement.
  • The trial demonstrates a cost-effective method for evaluating treatments using mobile technology and patient-reported outcomes.
  • This model offers a new paradigm for efficient clinical trial execution and evidence generation.