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[Hormonal influence on hearing].

J M Vahl1, E Goldberg-Bockhorn2, T K Hoffmann2

  • 1Klinik für Hals‑, Nasen‑, Ohrenheilkunde und Kopf-Hals-Chirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89070, Ulm, Deutschland. julius-malte.vahl@uniklinik-ulm.de.

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|March 16, 2021
PubMed
Summary
This summary is machine-generated.

Hormones show potential for treating acute hearing loss by protecting cochlear cells and influencing hair cell function. Further research is needed to explore their use in individualized patient treatment.

Keywords:
AldosteroneDeafnessEstrogenIntratympanicPresbyacusis

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Area of Science:

  • Oto-neurology
  • Endocrinology
  • Pharmacology

Background:

  • Hearing loss significantly impacts communication, social interaction, and cognitive function, necessitating early intervention.
  • Currently, no causal therapies exist for hearing loss.
  • Hormone-based treatments show promise for positive effects on hearing, supported by human and animal studies.

Purpose of the Study:

  • To review the effects of various hormones on hearing.
  • To explore the potential of hormone therapy for future audiological treatments.

Main Methods:

  • Systematic literature review of reviews on hormone effects on hearing.
  • Studies included human and animal research published in PubMed from 2015 to 2020.

Main Results:

  • Hormones may offer antiapoptotic effects on cochlear and auditory pathway cells.
  • Hormones can influence hair cell functionality and endo/perilymph electrolyte balance.
  • Research is ongoing for glucocorticoids, aldosterone, sex hormones (estrogen, progesterone, testosterone), growth hormones (GH, IGF-1), thyroid hormones, and insulin.
  • While results are inconsistent, hormones present a potential future treatment for acute hearing loss.
  • Long-term hormone therapy for age-related hearing loss is not currently feasible due to side effects and lack of topical application.

Conclusions:

  • Hormonal mechanisms in hearing are complex.
  • Further investigation is required to determine the viability of individualized hormone treatments for acute hearing impairment.