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Carcinoid Heart Disease: a Review
Faidon-Marios Laskaratos1, Joseph Davar2, Christos Toumpanakis3
1Neuroendocrine Tumour Unit, Centre for Gastroenterology, Royal Free Hospital, London, UK.
Current Oncology Reports
|March 16, 2021
Summary
Carcinoid heart disease (CHD), a complication of neuroendocrine neoplasms (NEN), requires early screening and multidisciplinary management. Prompt recognition and treatment improve outcomes for patients with this poor prognostic factor.
Area of Science:
- Cardiology
- Oncology
- Gastroenterology
Background:
- Carcinoid heart disease (CHD) is a fibrotic complication of neuroendocrine neoplasms (NEN).
- CHD is associated with a poor prognosis and affects up to 50% of neuroendocrine tumor (NET) patients with carcinoid syndrome.
- Early recognition is often missed, with diagnosis typically occurring late in symptomatic patients.
Purpose of the Study:
- To review the clinical features of CHD.
- To outline current investigations for CHD.
- To summarize management strategies for CHD.
Main Methods:
- Literature review of clinical features, investigations, and management of CHD.
- Analysis of screening strategies including biomarkers and multimodality imaging.
- Evaluation of multidisciplinary team approaches and therapeutic interventions.
Main Results:
- CHD is frequently underdiagnosed and recognized late in symptomatic patients.
- A proactive screening strategy utilizing biomarkers and imaging is essential for early detection.
- Multidisciplinary management, including medical therapy and surgical intervention, improves clinical outcomes.
- Centralized care and a team-based approach have recently improved outcomes for CHD-NET patients.
Conclusions:
- Early screening and diagnosis of CHD are critical for improving patient prognosis.
- A multidisciplinary approach involving experienced specialists is vital for optimal management.
- Timely intervention, including medical and surgical options, can enhance clinical outcomes in CHD patients.
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