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Biology of interleukin-38 and its role in chronic inflammatory diseases
Hua-Song Xia1, Yue Liu1, Yang Fu1
1Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Abstract:
Interleukin (IL)-38 is the tenth member of the IL-1 cytokine family. IL-38 shares high similarity with IL-36Ra and IL-1Ra and can bind to their receptors, thus exerting an anti-inflammatory effect. Despite the lack of a signal peptide, IL-38 can be released from several cell types, but its maturation process remains obscure. The role of IL-38 in numerous inflammatory diseases, especially in autoimmune diseases, has been extensively studied. In this review, we discuss the characteristics, biological functions and pathways of IL-38, as well as its role in several chronic inflammatory diseases. Better understanding the role of IL-38 will pave the way for clinical treatments in the near future.
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