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Updated: Nov 12, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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[COVID-19 and Headaches]

Heiko Pohl1, Andreas R Gantenbein1,2

  • 1Klinik für Neurologie, Universitätsspital Zürich.

Praxis
|March 17, 2021
PubMed

Insights

Headaches are a frequent symptom of COVID-19, often presenting as severe, frontal pain. While ibuprofen is safe for treatment, mask-wearing may trigger headaches, though lockdowns reduced migraine frequency.

Area of Science:

  • Neurology
  • Infectious Diseases

Background:

  • Headaches are a common manifestation of COVID-19.
  • COVID-19-associated headaches are typically bilateral, frontal, squeezing, and moderate to severe.

Purpose of the Study:

  • To characterize headaches associated with COVID-19.
  • To evaluate the safety of ibuprofen for COVID-19 headache treatment.
  • To explore the impact of COVID-19 and related measures on primary headaches.

Main Methods:

  • Review of clinical descriptions of COVID-19 headaches.
  • Analysis of prospective studies on ibuprofen use.
  • Observation of headache patterns during COVID-19 lockdowns and quarantine.

Main Results:

  • COVID-19 headaches are often accompanied by fever, cough, and elevated inflammatory markers, aiding differentiation from primary headaches.
  • No contraindications were found for ibuprofen use in managing COVID-19 headaches.
  • Facial mask use was linked to headaches, while lockdown measures decreased migraine frequency for some patients.

Conclusions:

  • Headache is a significant symptom of COVID-19 requiring symptomatic treatment.
  • Ibuprofen can be safely used for COVID-19-related headaches.
  • Public health measures influenced primary headache patterns, necessitating adaptive treatment strategies like telemedicine.

Keywords:
LockdownMaskeMigräneQuarantäneSARS-COV2confinementlockdownmaskmasquemigrainequarantainequarantine

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