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P(3HB-co-4HB) as high value polyhydroxyalkanoate: its development over recent decades and current advances
Kai-Hee Huong1, Vigneswari Sevakumaran2, A A Amirul1,3,4
1School of Biological Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Critical Reviews in Biotechnology
|March 17, 2021
Summary
Polyhydroxyalkanoate (PHA) is a biodegradable plastic. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] shows promise as a biocompatible healthcare biomaterial.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biotechnology
Background:
- Polyhydroxyalkanoate (PHA) offers a biodegradable and biocompatible alternative to synthetic plastics.
- Microbial fermentation of renewable resources enables PHA production.
- Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] exhibits significant potential as a next-generation healthcare biomaterial due to its mammalian tissue compatibility.
Purpose of the Study:
- To provide a comprehensive review of P(3HB-co-4HB) research.
- To assess the development and trends in P(3HB-co-4HB) over recent decades.
- To highlight P(3HB-co-4HB)'s applications in high-value healthcare products.
Main Methods:
- Review of scientific literature on P(3HB-co-4HB).
- Analysis of microbial strain discovery and development.
- Examination of metabolic engineering and bioprocess cultivation strategies.
Main Results:
- P(3HB-co-4HB) research has advanced significantly over the past decades.
- Various microbial strains and engineering strategies have been explored for P(3HB-co-4HB) production.
- Optimized bioprocesses are crucial for efficient P(3HB-co-4HB) cultivation.
Conclusions:
- P(3HB-co-4HB) is a promising biomaterial for advanced healthcare applications.
- Continued research in strain development and bioprocessing will enhance P(3HB-co-4HB) utility.
- The biocompatibility and biodegradability of P(3HB-co-4HB) underscore its value in the medical field.
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