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Published on: January 18, 2016
Role of rafts in neurological disorders
U Meza1, C Romero-Méndez1, S Sánchez-Armáss1
1Departamento de Fisiología y Biofísica. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
Introduction:
Rafts are function-structural cell membrane nano-domains. They contribute to explain the efficiency of signal transduction at the low physiological membrane concentrations of the signaling partners by their clustering inside specialized signaling domains.
Development:
In this article, we review the current model of the membrane rafts and their physio-pathological relevance in the nervous system, including their role in Parkinson, Alzheimer, and Huntington diseases.
Conclusions:
Rafts disruption/dysfunction has been shown to relate diverse neurological diseases. Therefore, it has been suggested that preservation of membrane rafts may represent a strategy to prevent or delay neuronal dysfunctions in several diseases.

