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Sequential therapies for advanced urothelial cancer: Hope meets new challenges

Daniel Herchenhorn1, Vinicius Freire2, Thamires Oliveira2

  • 1Grupo de Oncologia D'Or, Instituto D'Or de Ensino e Pesquisa, Brazil; Latin America Cooperative Oncology Group - LACOG, Brazil.

Critical Reviews in Oncology/Hematology
|March 17, 2021
PubMed

Insights

Recent advances in urothelial carcinoma (UC) treatment include new immunotherapies and targeted agents like anti-FGFR and anti-nectin-4 inhibitors. This review guides oncologists on integrating these novel therapies for advanced UC.

Area of Science:

  • Oncology
  • Urothelial Carcinoma Research
  • Medical Treatment Advancements

Background:

  • Advanced urothelial carcinoma (UC) treatment has seen significant evolution.
  • The last three years introduced immune check-point inhibitors for first and second-line therapies.

Purpose of the Study:

  • To review new classes of agents for advanced UC.
  • To explore the integration of novel therapies into clinical practice.
  • To guide oncologists on treatment sequencing for metastatic UC.

Main Methods:

  • Review of recent clinical trial data.
  • Analysis of preliminary results from randomized phase 3 trials.
  • Exploration of novel therapeutic agents including anti-FGFR and anti-nectin-4 inhibitors.

Main Results:

  • Approval of anti-FGFR and anti-nectin-4 inhibitors for refractory disease.
  • Positive preliminary results from randomized trials combining chemotherapy and immunotherapy.
  • Emergence of maintenance immunotherapy strategies post-chemotherapy induction.

Conclusions:

  • A new treatment paradigm for metastatic urothelial carcinoma has been established.
  • Novel agents and treatment combinations are reshaping clinical practice.
  • Evidence-based guidance is provided for sequencing advanced UC therapies.
Keywords:
Advanced urothelial cancerImmunotherapySequential therapiesTargeted agents

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